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Within mature secretory granules, once MPGF is generated, PC1/3 will first preferentially cleave MPGF at R77 and then cleave between R109 and R110, which renders the active forms of GLP-1, GLP-1(7–37) and GLP-1(7–36) (68, 71) as well as the N-terminally extended form of GLP-1 (68–72)
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